| Autor: |
Ying Song, Weiting Cai, Lin Jiang, Jingjing Xu, Yi Yao, Na Xu, Xiaozeng Wang, Zhenyu Liu, Zheng Zhang, Yongzhen Zhang, Xiaogang Guo, Zhifang Wang, Yingqing Feng, Qingsheng Wang, Jianxin Li, Xueyan Zhao, Jue Chen, Runlin Gao, Lei Song, Yaling Han, Jinqing Yuan |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-024-75508-9 |
| Popis: |
Abstract Although serum uric acid (SUA) is a risk factor for cardiometabolic outcome, but it remains unclear which patients with coronary artery disease (CAD) benefit the most from SUA lowering therapy (ULT). The association of SUA level, systemic inflammation and cardiometabolic risk is still unclear. The current study is aimed to examine whether SUA-associated cardiometabolic risk is modulated by systemic inflammation in CAD patients. A total of 16,598 CAD patients with baseline high-sensitivity C-Reactive Protein (hsCRP) and SUA available were included. Baseline and follow-up data were collected. The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE), including death, myocardial infarction and stroke. In patients with hsCRP ≥ 2 mg/L, increasing quintiles of SUA were significantly associated with increased rates of 2-year MACCE (adjusted p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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