Extracellular vesicle neurofilament light is elevated within the first 12-months following traumatic brain injury in a U.S military population

Autor: Vivian A. Guedes, Rael T. Lange, Sara M. Lippa, Chen Lai, Kisha Greer, Sara Mithani, Christina Devoto, Katie A. Edwards, Chelsea L. Wagner, Carina A. Martin, Angela E. Driscoll, Megan M. Wright, Kelly C. Gillow, Samantha M. Baschenis, Tracey A. Brickell, Louis M. French, Jessica M. Gill
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-05772-0
Popis: Abstract Traumatic brain injury (TBI) can be associated with long-term neurobehavioral symptoms. Here, we examined levels of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in extracellular vesicles isolated from blood, and their relationship with TBI severity and neurobehavioral symptom reporting. Participants were 218 service members and veterans who sustained uncomplicated mild TBIs (mTBI, n = 107); complicated mild, moderate, or severe TBIs (smcTBI, n = 66); or Injured controls (IC, orthopedic injury without TBI, n = 45). Within one year after injury, but not after, NfL was higher in the smcTBI group than mTBI (p = 0.001, d = 0.66) and IC (p = 0.001, d = 0.35) groups, which remained after controlling for demographics and injury characteristics. NfL also discriminated the smcTBI group from IC (AUC:77.5%, p
Databáze: Directory of Open Access Journals
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