| Autor: |
Mahmoud Abbas, Mario W. Kramer, Tilmann Spieker, Thomas R.W. Herrman, Axel S. Merseburger, Klaus-Michael Müller, Marcus A. Kuczyk, Jan U. Becker, Hans-Heinrich Kreipe |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Journal of the Egyptian National Cancer Institute, Vol 26, Iss 1, Pp 51-54 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1110-0362 |
| DOI: |
10.1016/j.jnci.2013.11.002 |
| Popis: |
Primary epithelial tumor of the renal pelvis is rare and only 100 cases are reported in the literature [1]. Histological examination of the tumor showed glands, cysts, and papillae lined by pseudostratified columnar epithelium with hyperchromatic nuclei. Scattered signet ring-type cells were also seen floating in large pools of extracellular mucin. Sections from the ureter showed a component of adenocarcinoma in situ. No invasive tumor was identified in ureteric tissue. One case was reported with carcinoma in situ of the ureter (2). Immunohistochemically: The tumor showed positivity for CK7, CK20, CK8/18, GATA-3, MSH-2, MSH-6, MLH-1, Ber-EP4, and S-100-P with focal positivity for CDX-2, weak positivity for PMS-2 and negativity in TTF-1 and Her-2. Molecular pathological analysis revealed microsatellite stability and without mutation in K-ras-gene. Thus, a diagnosis of mucinous adenocarcinoma of the renal pelvis with in situ adenocarcinoma of the ureter was made. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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