| Autor: |
Ruiying Li, Gongbo Chen, Mingming Pan, Xiaoyu Hou, Ning Kang, Ruoling Chen, Yinghao Yuchi, Wei Liao, Xiaotian Liu, Zhenxing Mao, Wenqian Huo, Yuming Guo, Shanshan Li, Chongjian Wang, Jian Hou |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Environment International, Vol 169, Iss , Pp 107496- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
0160-4120 |
| DOI: |
10.1016/j.envint.2022.107496 |
| Popis: |
Background: Both ambient ozone exposure and residential greenness are linked to the aging process. However, their interactive effect on molecular biomarkers of aging (telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN)) remains unclear. Methods: This study was conducted among 6418 rural Chinese adults. The concentration of ambient ozone was assessed using a random forest model. Residential greenness was represented by the normalized difference vegetation index (NDVI). Molecular biomarkers of aging (relative TL and relative mtDNA-CN) were determined by quantitative real-time polymerase chain reaction. Generalized linear regression models were applied to investigate the independent and combined effects of ambient ozone and residential greenness on relative TL and relative mtDNA-CN. Results: The estimated percent changes and 95 % confidence intervals (CIs) of relative TL in response to per-unit increase in ambient ozone were –22.43 % (–23.74 %, −21.18 %), −14.19 % (−15.63 %, −12.72 %) and −4.50 % (−6.57 %, −2.27 %) for participants with low (NDVI ≤ 0.53), moderate (0.54–0.55) and high (≥0.56) residential greenness exposure, respectively, while the corresponding figures of relative mtDNA-CN were −12.63 % (−13.84 %, −11.31 %), −9.52 % (−10.60 %, −8.33 %) and 2.12 % (0.20 %, 4.19 %). Furthermore, negative interactive effects between ambient ozone and residential greenness exposure on molecular biomarkers of aging were observed (P for interaction |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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