Primary EWS/PNET of the lung with TP53 germline and SKT11 somatic mutation: A case report and review of the literature

Autor:	Shuangping Zhang, Yun Chen, Shiping Guo, Ke‐Neng Chen
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Ewing's sarcoma pulmonary TP53 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Thoracic Cancer, Vol 13, Iss 1, Pp 137-140 (2022)
Druh dokumentu:	article
ISSN:	1759-7714 1759-7706
DOI:	10.1111/1759-7714.14251
Popis:	Abstract Primary pulmonary EWS/PNET is extremely rare. This report describes a 20 year‐old man with primary pulmonary EWS/PNET with TP53 germline and SKT11 somatic mutation. After four neoadjuvant chemotherapy cycles (VAC with alternating IE) combined with anlotinib, a left pneumonectomy was performed. Maintenance anlotinib monotherapy was then continued with no sign of recurrence to date. It is suggested that before the treatment and prognosis of children or young adults with primary EWS/PNET of the lung that consideration should be given to genetic testing.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/30b775c9c308423598a4b982b7d1c8dd Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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