| Autor: |
S. Ya. Loginova, V. N. Shchukina, S. V. Savenko, S. V. Borisevich |
| Jazyk: |
ruština |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Антибиотики и Химиотерапия, Vol 65, Iss 3-4, Pp 3-6 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0235-2990 |
| DOI: |
10.37489/0235-2990-2020-65-3-4-3-6 |
| Popis: |
The antiviral activity of the drug Kagocel®, which has a high safety profile and proven efficacy for the prevention and treatment of influenza and AVRI as an interferon inducer, was studied against a new pandemic strain of SARS-CoV-2 in vitro in Vero C1008 cell culture. The results of the study revealed that at the addition of the substance Kagocel® at the concentration of 5000 pg/ml into the cell culture 1 h before the virus infection and 1 h after, there was 100% inhibition of the cytopathic activity of the virus. It was also found that Kagocel® at the dose of 5000 pg/ml effectively suppressed the reproduction of the SARS-CoV-2 virus, variant B, in Vero C1008 cell culture by 1.75 lg, the inhibition coefficient was 97.83 %. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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