Clinical significance of the determination of matrix metalloproteinases in newborns with congenital herpes virus infection
| Autor: | S. N. Beniova, S. Yu. Figol, E. V. Markelova |
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| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Rossijskij Vestnik Perinatologii i Pediatrii, Vol 61, Iss 1, Pp 46-50 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1027-4065 2500-2228 |
| DOI: | 10.21508/1027-4065-2016-61-1-46-50 |
| Popis: | The time course of changes in the serum levels of matrix metalloproteinases (MMP-8, MMP-9) was studied in neonatal infants after perinatal exposure to herpes simplex virus in the early neonatal period to elaborate criteria for the early preclinical diagnosis of its infection and to define the severity of the pathological process. Fifty-seven infants born to mothers with chronic herpes virus infection were examined. MMP-8 and MMP-9 were determined by a solid-phase enzyme immunoassay using specific reagents (R&D Diagnostics Inc., USA). Different changes were found in MMP-8 and MMP-9 levels in relation to the onset of clinical symptoms of congenital herpes virus infection. The elevated plasma metalloproteinase levels in the first 24 hours after birth in newborn infants at risk for herpes virus infection may be regarded as preclinical markers for the manifestations of congenital infection. The magnitude of changes in serum metalloproteinase levels correlates with the severity of the disease. |
| Databáze: | Directory of Open Access Journals |
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