Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

Autor: Susanne Laukoter, Robert Beattie, Florian M. Pauler, Nicole Amberg, Keiichi I. Nakayama, Simon Hippenmeyer
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-14077-2
Popis: How the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projection neuron survival.
Databáze: Directory of Open Access Journals