The role of immunophenotyping in differential diagnosis of chronic lymphocytic leukemia

Autor: Dragović-Ivančević Tijana, Kraguljac-Kurtović Nada, Knežević Vesna, Bogdanović Andrija, Mihaljević Biljana, Božić Biljana, Gotić Mirjana
Jazyk: English<br />Serbian
Rok vydání: 2014
Předmět:
Zdroj: Srpski Arhiv za Celokupno Lekarstvo, Vol 142, Iss 3-4, Pp 197-203 (2014)
Druh dokumentu: article
ISSN: 0370-8179
DOI: 10.2298/SARH1404197D
Popis: Introduction. Accurate diagnosis of chronic lymphocytic leukemia (CLL) acquires immunophenotyping by flow cytometry in order to facilitate differential diagnosis between CLL and other mature B-cell neoplasms (MBCN). Objective. The aim of this study was to define immunological profile of CLL cells. Methods. Immunophenotyping by flow cytometry was performed on peripheral blood specimens at diagnosis in the group of 211 patients with de novo MBCN. Results. Absolute count of B-cells was significantly increased in all MBCN patients comparing to healthy control group (p
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