Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage

Autor: Ian Roberts, Haleema Shakur, Bukola Fawole, Modupe Kuti, Oladapo Olayemi, Adenike Bello, Olayinka Ogunbode, Taiwo Kotila, Chris O. Aimakhu, Tolulase Olutogun, Beverley J. Hunt, Sumaya Huque
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BMC Pregnancy and Childbirth, Vol 18, Iss 1, Pp 1-8 (2018)
Druh dokumentu: article
ISSN: 1471-2393
DOI: 10.1186/s12884-018-1794-1
Popis: Abstract Background Early treatment with tranexamic acid reduces deaths due to bleeding after post-partum haemorrhage. We report the prevalence of haematological, coagulation and fibrinolytic abnormalities in Nigerian women with postpartum haemorrhage. Methods We performed a secondary analysis of the WOMAN trial to assess laboratory data and rotational thromboelastometry (ROTEM) parameters in 167 women with postpartum haemorrhage treated at University College Hospital, Ibadan, Nigeria. We defined hyper-fibrinolysis as EXTEM maximum lysis (ML) > 15% on ROTEM. We defined coagulopathy as EXTEM clot amplitude at 5 min (A5) 1.5. Results Among the study cohort, 53 (40%) women had severe anaemia (haemoglobin
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