Inhibition of myeloid-derived suppressor cell arginase-1 production enhances T-cell-based immunotherapy against Cryptococcus neoformans infection

Autor: Ya-Nan Li, Zhong-Wei Wang, Fan Li, Ling-Hong Zhou, Yan-Shan Jiang, Yao Yu, Hui-Hui Ma, Li-Ping Zhu, Jie-Ming Qu, Xin-Ming Jia
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-31723-4
Popis: Cryptococcus neoformans causes opportunistic infection and potentially lethal immunopathology but therapeutic options are limited. Here the authors implicate myeloid derived suppressor cells during C. neoformans infection and suggest targeting arginase-1 production as a potential therapeutic strategy.
Databáze: Directory of Open Access Journals