Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?
| Autor: | Marjet Elemans, Nafisa-Katrin Seich Al Basatena, Nichole R Klatt, Christos Gkekas, Guido Silvestri, Becca Asquith |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | PLoS Computational Biology, Vol 7, Iss 9, p e1002200 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1553-734X 1553-7358 |
| DOI: | 10.1371/journal.pcbi.1002200 |
| Popis: | In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo. |
| Databáze: | Directory of Open Access Journals |
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