SS-68 IMPACT ON THE CONTRACTIVE ACTIVITY OF ISOLATED VESSELS
| Autor: | A. V. Zelenskaya, S. K. Bogus, K. F. Suzdalev, P. A. Galenko-Yaroshevsky |
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| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Кубанский научный медицинский вестник, Iss 6, Pp 62-66 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1608-6228 2541-9544 |
| Popis: | In the experiments on isolated circular segments of the thoracic aorta of a rat it has been proved that indole SS-66 derivative in 10-5 and 10-4 М concentrations can relax smooth muscle cells (SMS) due to its impact on the SMS potassium conduction thus facilitating their hyperpolarization. It results in the block of voltage-sensitive calcium channels, the decrease in calcium input and the SMS relaxing. Lack of the NO-synthase Nω-nitro-L-arginine blocker impact on this process indicates of the lack of the SS-68 impact on the processes connected with the endothelium-dependant SMS relaxation. |
| Databáze: | Directory of Open Access Journals |
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