Biocompatibility of mineral trioxide aggregate and three new endodontic cements: An animal study

Autor: Mohammad-Ghasem Aminozarbian, Masoud Barati, Iman Salehi, Seyed Behrouz Mousavi
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Dental Research Journal, Vol 9, Iss 1, Pp 54-59 (2012)
Druh dokumentu: article
ISSN: 1735-3327
2008-0255
DOI: 10.4103/1735-3327.92944
Popis: Background: Introducing new endodontic cements should await comprehensive investigations and new formulations have to be tested in vivo before applying in human beings. So, the purpose of this study was to compare the biocompatibility of new endodontic cements, calcium aluminate α-aluminate cement (CAAC), calcium aluminate α-aluminate plus cement (CAAC plus), and a mixture of wollastonite and CAAC cement (WOLCA) and mineral trioxide aggregate (MTA), in subcutaneous connective tissue of rats. Materials and Methods: Twenty-seven Wistar rats were divided into three groups of 7, 14, and 30 experimental days. Sterile polyethylene tubes were filled with MTA, CAAC, CAAC Plus, and WOLCA cement and implanted subcutaneously. Empty tubes were implanted as negative control. After the experimental periods, animals were sacrificed by anesthetic overdosing. The occurrence of inflammatory responses was scored according to the previously established scores. Data were statistically analyzed using Friedman, Wilcoxon, Kruskal-Wallis, and Mann-Whitney tests. The level of significance was 5% (P
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