| Autor: |
Daniela Andriuta, Joel Ramirez, Fuqiang Gao, Jennifer Rabin, Madeline E Wood, Paula M McLaughlin, Christopher JM Scott, Miracle Ozzoude, Allison A Dilliott, Robert A Hegele, Maria C Tartaglia, David Tang-Wai, Richard H Swartz, Leanne Casaubon, Sanjeev Kumar, Dar Dowlatshahi, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Corinne Fischer, Michael Borrie, Ayman Hassan, Malcolm A Binns, Morris Freedman, Elizabeth Finger, Andrew Frank, Robert Bartha, Sean Symons, Mario Masellis, Sandra E Black |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100292- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-2450 |
| DOI: |
10.1016/j.cccb.2024.100292 |
| Popis: |
Introduction: MRI-visible perivascular spaces (PVS) are a neuroimaging feature of cerebral small vessel disease and are commonly observed in patients with cerebrovascular and neurodegenerative disease. However, it is unclear whether PVS burden is associated with cognition. The aim of this study was to investigate the potential associations between PVS volumes, brain atrophy, white matter hyperintensities (WMH), and speeded executive function, in patients from the Ontario Neurodegenerative Disease Research Initiative (ONDRI). Methods: ONDRI participants (n=333) clinically diagnosed with Alzheimer's disease/mild cognitive impairment (ADMCI), frontotemporal dementia (FTD), and cerebrovascular diseases (CVD), with clinical, neuropsychological, MRI, plasma biomarkers (glial fibrillary acidic protein (GFAP); neurofilament light, (NfL); p-tau181; Aβ42/40), and available apolipoprotein E epsilon 4 (APOE E4) status, were included in this analysis. MRI-based measurements for brain parenchymal fraction (BPF), lacunes, PVS and WMH were extracted using the ONDRI imaging pipeline. The neuropsychological test scores were standardized (z-transformed), speeded executive function z- scores were computed as the mean of digit symbol modalities test and trail making test part B timed z-scores. The variables selected in bivariate analysis (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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