The Relationship between IL-1β-511 Polymorphism and Gastric Cancer in Ardabil Province, Iran
| Autor: | Effat Seyedhashemi, Elham Niasti, Nima Farahmand, Mohammad Mazani, Abbas Yazdanbod, Firouz Amani, Seyyed Saeid Hossini-Asl |
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| Jazyk: | perština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Journal of Ardabil University of Medical Sciences, Vol 19, Iss 4, Pp 410-417 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2228-7280 2228-7299 |
| Popis: | Background & objectives: Gastric cancer has a very wide geographic distribution. Identification of the genetic factors involved in the cancer predisposition is very important. IL-1β as a pro inflammatory cytokine is involved in gastric acid secretion in the H. pylori infected individuals. This study was aimed to evaluate the role of IL-1β-511 polymorphism on the susceptibility to gastric cancer in residents of Ardabil province. Methods: One-hundred patients affected with gastric cancer and 100 normal individuals were selected as case and control groups, respectively. After DNA extraction from peripheral blood samples, the presence of the polymorphism IL-1β-511 was determined via PCR-RFLP assay. The results were evaluated by agarose gel electrophoresis. Results: Among cases, CC, CT, and TT genotypes were observed in 19%, 60%, and 21% of individuals, respectively. Also, the distribution of genotypes among the participated individuals in control group was 4%, 67%, and 29%, respectively. There was a significant difference (p |
| Databáze: | Directory of Open Access Journals |
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