| Autor: |
Kenny D Kronforst, Christy J Mancuso, Matthew Pettengill, Jana Ninkovic, Melanie R Power Coombs, Chad Stevens, Michael Otto, Carina Mallard, Xiaoyang Wang, Donald Goldmann, Ofer Levy |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 7, Iss 9, p e43897 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0043897 |
| Popis: |
Staphylococcus epidermidis (SE) causes late onset sepsis and significant morbidity in catheterized preterm newborns. Animal models of SE infection are useful in characterizing disease mechanisms and are an important approach to developing improved diagnostics and therapeutics. Current murine models of neonatal bacterial infection employ intraperitoneal or subcutaneous routes at several days of age, and may, therefore, not accurately reflect distinct features of innate immune responses to bacteremia. In this study we developed, validated, and characterized a murine model of intravenous (IV) infection in neonatal mice |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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