Clinical treatment strategy and follow-up of lymphoepithelioma-like carcinoma: a retrospective study
Autor: | Shilong Zhang, Yufu Lin, Zhiyong Li, Zhiming Wang, Rongkui Luo, Xiuping Zhang |
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Jazyk: | angličtina |
Rok vydání: | 2024 |
Předmět: | |
Zdroj: | Future Science OA, Vol 10, Iss 1 (2024) |
Druh dokumentu: | article |
ISSN: | 20565623 2056-5623 |
DOI: | 10.1080/20565623.2024.2384878 |
Popis: | Aim: To investigate the clinical features, diagnosis and treatment of lymphoepithelioma-like carcinoma (LELC).Materials & methods: The clinical data of 114 LELC patients were retrospectively analyzed.Results: Ninety-eight patients (86.0%) were Epstein-Barr virus-encoded small RNA (EBER) positive detected by situ hybridization. A 67.1% (51/76) patients had PD-L1 expression. The 5-year overall survival rate of EBER negative patients was 51.6% while the rate of positive patients was 84.8% (p = 0.015). The 5-year progression free survival rate of EBER negative patients was 40.2% while the rate of positive patients was 70.2% (p = 0.004).Conclusion: The progression of LELC is relatively slow and present a better prognosis. The occurrence of tumor is closely related to Epstein–Barr virus infection and PD-L1 is highly expressed in tumor cells. |
Databáze: | Directory of Open Access Journals |
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