Clinical treatment strategy and follow-up of lymphoepithelioma-like carcinoma: a retrospective study

Autor: Shilong Zhang, Yufu Lin, Zhiyong Li, Zhiming Wang, Rongkui Luo, Xiuping Zhang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Future Science OA, Vol 10, Iss 1 (2024)
Druh dokumentu: article
ISSN: 20565623
2056-5623
DOI: 10.1080/20565623.2024.2384878
Popis: Aim: To investigate the clinical features, diagnosis and treatment of lymphoepithelioma-like carcinoma (LELC).Materials & methods: The clinical data of 114 LELC patients were retrospectively analyzed.Results: Ninety-eight patients (86.0%) were Epstein-Barr virus-encoded small RNA (EBER) positive detected by situ hybridization. A 67.1% (51/76) patients had PD-L1 expression. The 5-year overall survival rate of EBER negative patients was 51.6% while the rate of positive patients was 84.8% (p = 0.015). The 5-year progression free survival rate of EBER negative patients was 40.2% while the rate of positive patients was 70.2% (p = 0.004).Conclusion: The progression of LELC is relatively slow and present a better prognosis. The occurrence of tumor is closely related to Epstein–Barr virus infection and PD-L1 is highly expressed in tumor cells.
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