Sustained Complete Remission in Multi-Relapsed Primary CNS Lymphoma Treated with Ibrutinib Monotherapy: A Case Report

Autor:	Anna Mair, Armin Muigg, Günther Stockhammer, Stephanie Mangesius, Dominik Wolf, Eberhard Gunsilius
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	ibrutinib primary cns lymphoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 14, Iss 3, Pp 1337-1341 (2021)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000518528
Popis:	Primary CNS lymphoma (PCNSL) is a highly aggressive malignant disease with a high recurrence rate and a poor prognosis. We present the case of a 71-year-old woman diagnosed with PCNSL in June 2010. After 3 relapses and intensive treatment with multiple chemotherapy regimens and whole-brain radiotherapy, she received off-label treatment with the Bruton tyrosine kinase inhibitor ibrutinib, responded well, achieved a complete remission, and is progression-free for now >3 years.
Databáze:	Directory of Open Access Journals
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