The clinical significance of hyperglycemia in nondiabetic critically ill multiple trauma patients
| Autor: | Leonid Koyfman, Evgeni Brotfain, Dmitry Frank, Yoav Bichovsky, Inna Kovalenko, Yair Benjamin, Abraham Borer, Michael Friger, Moti Klein |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Endocrinology and Metabolism, Vol 9 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2042-0188 2042-0196 20420188 |
| DOI: | 10.1177/2042018818779746 |
| Popis: | Background: Information is inconsistent regarding the clinical role of acute elevations of blood glucose level secondary to hospital-acquired infections in nondiabetic critically ill patients during an intensive care unit stay. In this study we investigated the clinical significance of hyperglycemia related to new episodes of ventilator-associated pneumonia in nondiabetic critically ill multiple trauma intensive care unit patients. Materials and Methods: We analyzed the clinical data of 202 critically ill multiple trauma patients with no history of previous diabetes who developed a new ventilator-associated pneumonia episode during their intensive care unit stay. We used a time-from-event analysis method to assess whether acute changes in blood glucose levels that occurred prior to the onset of ventilator-associated pneumonia episodes had a different prognostic significance from those that occurred during such episodes. Glucose levels and other laboratory data were recorded for up to 5 days before ventilator-associated pneumonia events and for 5 days following these events. Results: Patients who required insulin therapy for persistent hyperglycemia related to a new ventilator-associated pneumonia event had a longer period of intensive care unit stay and a higher intensive care unit mortality rate than patients who did not require insulin for blood glucose control ( p < 0.008 and |
| Databáze: | Directory of Open Access Journals |
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