Postoperative mometasone irrigations improve quality of life in skull base tumor patients

Autor: Mandy K. Salmon, Rijul S. Kshirsagar, Jacob G. Eide, Auddie M. Sweis, Kathleen Davin, Aman Prasad, Heather Ungerer, Elizabeth Stevens, Kevin Ig‐Izevbekhai, Siddhant Tripathi, Tran B. Locke, Theodore Lin, Brian M. Sweis, Michael A. Kohanski, Nithin D. Adappa, James N. Palmer
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: World Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 9, Iss 4, Pp 314-319 (2023)
Druh dokumentu: article
ISSN: 2589-1081
2095-8811
DOI: 10.1002/wjo2.99
Popis: Abstract Objectives The use of topical corticosteroids to manage postoperative sinonasal symptoms after endoscopic skull base surgery (ESBS) has not been well studied. We quantified long‐term impact of postoperative steroid irrigations (SIs) on quality of life of patients after ESBS. Methods Retrospective review of patients at the University of Pennsylvania undergoing ESBS from 2010 to 2019. Data on patient demographics and postoperative treatment with nasal saline irrigation twice daily with and without dissolved steroids (mometasone or budesonide) was collected. Preoperative, and 1‐, 3‐, 6‐, 12‐, 18‐, and 24‐month postoperative Sino‐Nasal Outcome Test (SNOT‐22) scores were assessed. Results A total of 727 patients were assessed (53.4% males), with 479 patients in the no SI group and 248 patients in the SI group. Preoperative SNOT‐22 scores did not differ significantly (P = 0.19). 1‐, 3‐, 6‐, 12‐, 18‐, and 24‐month post‐op SNOT‐22 scores did not significantly differ between groups. However, mometasone irrigations resulted in significantly lower postoperative 2‐year SNOT‐22 scores compared to budesonide (P
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