| Autor: |
Salim Shah, Bertram Pitt, D. Craig Brater, Peter U. Feig, Wen Shen, Fatima S. Khwaja, Christopher S. Wilcox |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 10 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.117.006135 |
| Popis: |
BackgroundLoop diuretics are highly natriuretic but their short duration of action permits postdiuretic sodium retention, which limits salt loss unless dietary salt is severely restricted. We tested the hypothesis that a more prolonged duration of action would enhance salt loss. Methods and ResultsTen healthy participants were crossed over between 20 mg of oral immediate‐release or extended‐release (ER) torsemide while consuming a fixed diet with 300 mmol·d−1 of Na+. Compared with immediate‐release, plasma torsemide after ER was 59% lower at 1 to 3 hours but 97% higher at 8 to 10 hours as a result of a >3‐fold prolongation of time to maximal plasma concentrations. The relationship of natriuresis to log torsemide excretion showed marked hysteresis, but participants spent twice as long with effective concentrations of torsemide after ER, thereby enhancing diuretic efficiency. Compared with immediate‐release, ER torsemide did not reduce creatinine clearance and increased fluid (1634±385 versus 728±445 mL, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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