较高的血糖波动与较高的心血管疾病风险相关:来自糖尿病患者汇总分析的观点

Autor: Feng Li, Lei Zhang, Yun Shen, Huan‐Huan Liu, Zhen‐Ye Zhang, Gang Hu, Ru‐Xing Wang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Diabetes, Vol 15, Iss 5, Pp 368-381 (2023)
Druh dokumentu: article
ISSN: 1753-0407
1753-0393
DOI: 10.1111/1753-0407.13386
Popis: Abstract Background The relationship between glucose fluctuation and the risk of cardiovascular disease (CVD) in patients with diabetes remains elusive. Glycated hemoglobin (HbA1c) variability is a key parameter of glucose fluctuation. Methods PubMed, Cochrane Library, Web of Science, and Embase were searched up to 1 July 2022. Studies reporting associations of HbA1c variability (HbA1c‐SD), coefficient of variation of HbA1c (HbA1c‐CV), and HbA1c variability score [HVS] with the risk of CVD among patients with diabetes were included. We used three different insights (a high‐low value meta‐analysis, a study‐specific meta‐analysis, and a non‐linear dose–response meta‐analysis) to explore the relationship between HbA1c variability and CVD risk. A subgroup analysis was also performed to screen the potential confounding factors. Results A total of 14 studies with 254 017 patients with diabetes were eligible. The highest HbA1c variability was significantly associated with increased risks of CVD (HbA1c‐SD, risk ratio [RR] 1.45; HbA1c‐CV, RR 1.74; HVS, RR 2.46; all p 1 (all p
Databáze: Directory of Open Access Journals
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