Antiviral immunity within neural stem cells distinguishes Enterovirus-D68 strain differences in forebrain organoids

Autor:	Christine Vazquez, Seble G. Negatu, Carl D. Bannerman, Sowmya Sriram, Guo-Li Ming, Kellie A. Jurado
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	EV-D68 Innate immunity Central nervous system Forebrain organoids Neurons Neural stem cell Neurology. Diseases of the nervous system RC346-429
Zdroj:	Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Druh dokumentu:	article
ISSN:	1742-2094
DOI:	10.1186/s12974-024-03275-5
Popis:	Abstract Neural stem cells have intact innate immune responses that protect them from virus infection and cell death. Yet, viruses can antagonize such responses to establish neuropathogenesis. Using a forebrain organoid model system at two developmental time points, we identified that neural stem cells, in particular radial glia, are basally primed to respond to virus infection by upregulating several antiviral interferon-stimulated genes. Infection of these organoids with a neuropathogenic Enterovirus-D68 strain, demonstrated the ability of this virus to impede immune activation by blocking interferon responses. Together, our data highlight immune gene signatures present in different types of neural stem cells and differential viral capacity to block neural-specific immune induction.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e300f8d4ec874862bf49f7c9afbf789c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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