| Autor: |
Wolfgang Arns, Aurélie Philippe, Vanessa Ditt, Ingeborg A. Hauser, Friedrich Thaiss, Claudia Sommerer, Barbara Suwelack, Duska Dragun, Jan Hillen, Christiane Schiedel, Anja Elsässer, Björn Nashan |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Transplantation, Vol 2 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2813-2440 |
| DOI: |
10.3389/frtra.2023.1264903 |
| Popis: |
BackgroundStudies prospectively monitoring de novo donor-specific antibodies (dnDSAs) and their clinical impact are sparse. This substudy of ATHENA was initiated to evaluate the effect of everolimus (EVR) or mycophenolic acid (MPA) in combination with reduced calcineurin inhibitor (CNI, tacrolimus [TAC] or cyclosporine [CsA]) on the formation of human leukocyte antibodies (HLA), including dnDSA, and the impact on clinical outcomes in kidney transplant (KTx) recipients.MethodsAll eligible patients were randomized 1:1:1 to receive either EVR + TAC, EVR + CsA or MPA + TAC, with basiliximab induction plus steroids after transplantation up to Month 12. The incidence of dnDSA by treatment group and the association with clinical events were evaluated descriptively as an exploratory objective in the intent-to-treat (ITT) and per-protocol (PP) populations with at least one antibody assessment.ResultsOverall, none of the patients in the EVR + TAC group had either dnDSA or antibody mediated rejection (PP or ITT population) and only one patient with dnDSA in the TAC + MPA group had antibody mediated rejection.ConclusionThe EVR regimen was comparable to MPA regimen with an extremely low incidence of dnDSA over 1 year of treatment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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