| Autor: |
Minchenko Oleksandr H., Abramchuk Anastasiia I., Khita Olena O., Sliusar Myroslava Y., Viletska Yuliia M., Minchenko Dmytro O. |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Endocrine Regulations, Vol 58, Iss 1, Pp 206-214 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1336-0329 |
| DOI: |
10.2478/enr-2024-0024 |
| Popis: |
Objective. Carboxypeptidase E (CPE) plays an important role in the biosynthesis of neurotransmitters and peptide hormones including insulin. It also promotes cell proliferation, survival, and invasion of tumor cells. The endoplasmic reticulum stress, hypoxia, and nutrient supply are significant factors of malignant tumor growth including glioblastoma. There are data indicating that the knockdown of the endoplasmic reticulum to nucleus signaling 1 (ERN1) suppressed glioblastoma cell proliferation and increased invasiveness of these cells. The present study aims to investigate the regulation of the CPE gene in U87MG glioblastoma cells by ERN1 knockdown, hypoxia, and glucose or glutamine deprivations with the intent to reveal the role of ERN1 signaling in the regulation of this gene expression and function in tumorigenesis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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