| Autor: |
Min Woo Kim, Seung Hyeon Yu, Un Yang, Ryota Nukiwa, Hyeon Jung Cho, Nam Seop Kwon, Moon Jung Yong, Nam Ho Kim, Sang Hyeon Lee, Jun Ho Lee, Jae Hong Lim, Yoshiki Kohmura, Tatsuya Ishikawa, Frank S. Henry, Yumiko Imai, Seung Soo Oh, Hyung Ju Hwang, Akira Tsuda, Jung Ho Je |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Advanced Science, Vol 11, Iss 33, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2198-3844 |
| DOI: |
10.1002/advs.202306256 |
| Popis: |
Abstract It is self‐evident that our chests expand and contract during breathing but, surprisingly, exactly how individual alveoli change shape over the respiratory cycle is still a matter of debate. Some argue that all the alveoli expand and contract rhythmically. Others claim that the lung volume change is due to groups of alveoli collapsing and reopening during ventilation. Although this question might seem to be an insignificant detail for healthy individuals, it might be a matter of life and death for patients with compromised lungs. Past analyses were based on static post‐mortem preparations primarily due to technological limitations, and therefore, by definition, incapable of providing dynamic information. In contrast, this study provides the first comprehensive dynamic data on how the shape of the alveoli changes, and, further, provides valuable insights into the optimal lung volume for efficient gas exchange. It is concluded that alveolar micro‐dynamics is nonlinear; and at medium lung volume, alveoli expand more than the ducts. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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