| Autor: |
Jinong Feng, Zhifang Zhang, Xiwei Wu, Allen Mao, Frances Chang, Xutao Deng, Harry Gao, Ching Ouyang, Kenneth J Dery, Keith Le, Jeffrey Longmate, Claudia Marek, R Paul St Amand, Theodore G Krontiris, John E Shively |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 8, Iss 6, p e65033 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0065033 |
| Popis: |
Fibromyalgia syndrome (FMS) is a chronic musculoskeletal pain disorder affecting 2% to 5% of the general population. Both genetic and environmental factors may be involved. To ascertain in an unbiased manner which genes play a role in the disorder, we performed complete exome sequencing on a subset of FMS patients. Out of 150 nuclear families (trios) DNA from 19 probands was subjected to complete exome sequencing. Since >80,000 SNPs were found per proband, the data were further filtered, including analysis of those with stop codons, a rare frequency ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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