Higher NAFLD fibrosis score is associated with impaired eGFR

Autor: Meng-Hsuan Hsieh, Kuan-Ta Wu, Yi-Yu Chen, Jeng-Fu Yang, Wen-Yi Lin, Ning-Chia Chang, Chia-Yi Lin, Chao-Kuan Huang, Chao-Ling Wang, Hung-Yi Chuang, Shu-Ching Lin, Yu-Kuei Hsu, Yi-Shan Tsai, Wan-Long Chuang, Ming-Lung Yu, Chia-Yen Dai
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of the Formosan Medical Association, Vol 119, Iss 1, Pp 496-503 (2020)
Druh dokumentu: article
ISSN: 0929-6646
DOI: 10.1016/j.jfma.2019.07.007
Popis: Background/Purpose: Chronic kidney disease (CKD) has become a worldwide health problem, leading to high morbidity and mortality, and non-alcoholic fatty liver disease (NAFLD) is considered a risk factor for CKD. The aim of this study was to explore the relationship between NAFLD fibrosis score (NFS) and the estimated glomerular filtration rate (eGFR), and identify possible risk factors related to the NFS among Taiwanese subjects. Methods: Subjects were enrolled from the database of the Department of Preventive Medicine of Kaohsiung Municipal Hsiao-Kang Hospital. The eGFR was calculated according to the Taiwanese Modification of Diet in Renal Disease (TMDRD) equation, and the NFS was employed to evaluate the fibrotic level. Results: In total, 11,376 subjects were enrolled in this study, with a mean age of 52.0 ± 6.81 years, including 4529 (39.8%) males. A fasting sugar level ≥100 mg/dL (OR = 1.70, 95% CI = 1.52–1.87) and an abnormal waist circumference (OR = 1.81, 95% CI = 1.65–1.99) were significant factors associated with NFS (p
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