| Autor: |
Hussein M Khaled, Thoraya M Abdelhamid, Fouad M Abu-Taleb, Niveen M El-Hifnawi, Ahmad B Waley |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Future Science OA, Vol 5, Iss 9 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2056-5623 |
| DOI: |
10.2144/fsoa-2019-0076 |
| Popis: |
Aim & methods: To assess the impact of pretreatment serum levels of IL-18 and soluble IL-2 receptor (sIL-2R) on the clinical outcome of patients with diffuse large B-cell lymphoma treated with an R-CHOP protocol. Total 73 patients were included. Results: Elevated serum IL-18 (using mean as cutoff) was associated with numerically lower complete remission, and 3-year disease-free survival rates; however, the difference was not statistically significant. Nevertheless, the 3-year overall survival rates were significantly more favorable for the lower serum level group. Correspondingly, the complete remission, 3-year disease-free survival and overall survival rates for patients with low pretreatment sIL-2R levels were significantly better than individuals with higher levels. Conclusion: There is a growing body of evidence supporting the utility of pretreatment serum levels of sIL-2R and IL-18 as prognostic factors in diffuse large B-cell lymphoma patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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