Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?

Autor: Matthew J. Sharman, Erika Gyengesi, Huazheng Liang, Pratishtha Chatterjee, Tim Karl, Qiao-Xin Li, Markus R. Wenk, Barry Halliwell, Ralph N. Martins, Gerald Münch
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Neurobiology of Disease, Vol 124, Iss , Pp 505-519 (2019)
Druh dokumentu: article
ISSN: 1095-953X
DOI: 10.1016/j.nbd.2018.11.026
Popis: Increasingly, evidence is accumulating pointing at a protective role of a healthy diet at decreasing the risk of Alzheimer's disease. To test the effectiveness of nutritional components, the following food-derived compounds: curcumin alone (curcumin), curcumin combined with (−)epigallocatechin-3-gallate (EGCG), docosahexaenoic acid (DHA) and α-lipoic acid (ALA) (curcumin + EDA), or a combination of EGCG, DHA and ALA (EDA) were assessed in male Tg2576 transgenic mice on amyloid plaque load, amyloid levels (Aβ40/Aβ42, but not oligomers due to tissue limitations), microglial activation and memory using the contextual and cued fear conditioning test. The combination diet EDA, resulted in the strongest reduction of amyloid plaque load in both the cortical (p
Databáze: Directory of Open Access Journals
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