| Autor: |
Nathan Shen, Polly Creveling, Joshua J. Horns, Josh Bleicher, John Hyngstrom, Tawnya Bowles, Michael Andreae, Tracy Onega, Elliot A. Asare |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Heliyon, Vol 10, Iss 22, Pp e40353- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2024.e40353 |
| Popis: |
Background: Viral infections (VIs) have been linked to T-cell exhaustion, a state that impacts the immune system's ability to mount an effective anti-tumor response. This immunosuppressive effect may potentially worsen outcomes in melanoma patients. This study investigates the relationship between a history of VIs and melanoma-specific mortality, with the goal of understanding whether prior history of Vis contribute to an increased risk of mortality in melanoma patients. Materials and methods: A retrospective review of patients in the Utah Population Database (1997–2020) was done. There were 17,754 eligible melanoma patients, with 2286 also having a history of viral infections. Multivariable Cox proportional hazard models were used to assess the effect of VI on melanoma-specific mortality. Results: History of VI was associated with a higher risk of melanoma-specific mortality (HR = 1.33, 95 % CI: 1.07–1.65, P = 0.01). No differences were observed in mortality among patients undergoing surgery and adjuvant immunotherapy. Conclusions: A history of viral infections was associated with higher melanoma-specific mortality. The mechanism of this association and relationship with different types of viral infections and duration of infections remain to be elucidated. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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