| Autor: |
Keigo Kusuzawa, Keiko Suzuki, Hideshi Okada, Kodai Suzuki, Chihiro Takada, Soichiro Nagaya, Ryu Yasuda, Haruka Okamoto, Takuma Ishihara, Hiroyuki Tomita, Yuki Kawasaki, Toru Minamiyama, Ayane Nishio, Hirotsugu Fukuda, Takuto Shimada, Yuto Tamaoki, Tomoki Yoshida, Yusuke Nakashima, Naokazu Chiba, Genki Yoshimura, Ryo Kamidani, Tomotaka Miura, Hideaki Oiwa, Fuminori Yamaji, Yosuke Mizuno, Takahito Miyake, Yuichiro Kitagawa, Tetsuya Fukuta, Tomoaki Doi, Akio Suzuki, Takahiro Yoshida, Nobuyuki Tetsuka, Shozo Yoshida, Shinji Ogura |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Frontiers in Medicine, Vol 8 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2296-858X |
| DOI: |
10.3389/fmed.2021.791309 |
| Popis: |
Glycocalyx is present on the surface of healthy endothelium, and the concentration of serum syndecan-1 can serve as an injury marker. This study aimed to assess endothelial injury using serum syndecan-1 as a marker of endothelial glycocalyx injury in patients who underwent hemodialysis. In this single-center, retrospective, observational study, 145 patients who underwent hemodialysis at the Gifu University Hospital between March 2017 and December 2019 were enrolled. The median dialysis period and time were 63 months and 3.7 h, respectively. The serum syndecan-1 concentration significantly increased from 124.6 ± 107.8 ng/ml before hemodialysis to 229.0 ± 138.1 ng/ml after hemodialysis (P < 0.001). Treatment with anticoagulant nafamostat mesylate inhibited hemodialysis-induced increase in the levels of serum syndecan-1 in comparison to unfractionated heparin. Dialysis time and the change in the syndecan-1 concentration were positively correlated. Conversely, the amount of body fluid removed and the changes in the syndecan-1 concentration were not significantly correlated. The reduction in the amount of body fluid removed and dialysis time inhibited the change in the syndecan-1 levels before and after hemodialysis. In conclusion, quantitative assessment of the endothelial glycocalyx injury during hemodialysis can be performed by measuring the serum syndecan-1 concentration, which may aid in the selection of appropriate anticoagulants, reduction of hemodialysis time, and the amount of body fluid removed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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