Association between timing of operative interventions and mortality in emergency general surgery

Autor: Katherine M Reitz, Joshua B Brown, Matthew D Neal, David S Silver, Liling Lu, Jamison Beiriger, Yekaterina Khamzina, Andrew B Peitzman
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Trauma Surgery & Acute Care Open, Vol 9, Iss 1 (2024)
Druh dokumentu: article
ISSN: 2397-5776
DOI: 10.1136/tsaco-2024-001479
Popis: Background Emergency general surgery (EGS) often demands timely interventions, yet data for triage and timing are limited. This study explores the relationship between hospital arrival-to-operation time and mortality in EGS patients.Study design We performed a retrospective cohort study using an EGS registry at four hospitals, enrolling adults who underwent operative intervention for a primary American Association for the Surgery of Trauma-defined EGS diagnosis between 2021 and 2023. We excluded patients undergoing surgery more than 72 hours after admission as non-urgent and defined our exposure of interest as the time from the initial vital sign capture to the skin incision timestamp. We assessed the association between operative timing quintiles and in-hospital mortality using a mixed-effect hierarchical multivariable model, adjusting for patient demographics, comorbidities, organ dysfunction, and clustering at the hospital level.Results A total of 1199 patients were included. The median time to operating room (OR) was 8.2 hours (IQR 4.9–20.5 hours). Prolonged time to OR increased the relative likelihood of in-hospital mortality. Patients undergoing an operation between 6.7 and 10.7 hours after first vitals had the highest odds of in-hospital mortality compared with operative times
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