Osteopetrosis and Its Relevance for the Discovery of New Functions Associated with the Skeleton

Autor: Amélie E. Coudert, Marie-Christine de Vernejoul, Maurizio Muraca, Andrea Del Fattore
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: International Journal of Endocrinology, Vol 2015 (2015)
Druh dokumentu: article
ISSN: 1687-8337
1687-8345
DOI: 10.1155/2015/372156
Popis: Osteopetrosis is a rare genetic disorder characterized by an increase of bone mass due to defective osteoclast function. Patients typically displayed spontaneous fractures, anemia, and in the most severe forms hepatosplenomegaly and compression of cranial facial nerves leading to deafness and blindness. Osteopetrosis comprises a heterogeneous group of diseases as several forms are known with different models of inheritance and severity from asymptomatic to lethal. This review summarizes the genetic and clinical features of osteopetrosis, emphasizing how recent studies of this disease have contributed to understanding the central role of the skeleton in the whole body physiology. In particular, the interplay of bone with the stomach, insulin metabolism, male fertility, the immune system, bone marrow, and fat is described.
Databáze: Directory of Open Access Journals