Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes

Autor: Richard Thomson-Luque, Lasse Votborg-Novél, Wanangwa Ndovie, Carolina M. Andrade, Moussa Niangaly, Charalampos Attipa, Nathalia F. Lima, Drissa Coulibaly, Didier Doumtabe, Bouréima Guindo, Bourama Tangara, Fayçal Maiga, Abdoulaye Kassoum Kone, Karim Traore, Kassoum Kayentao, Aissata Ongoiba, Safiatou Doumbo, Mahamadou A. Thera, Boubacar Traoré, Karl Seydel, Nuno S. Osório, Silvia Portugal
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-25062-z
Popis: To understand malaria symptoms, several studies investigate association between parasite’s transcriptome and disease severity. Here, Thomson-Luque et al. reanalyze available transcriptomic data of P. falciparum and find that longer circulation of infected erythrocytes without sequestering to endothelial cells associates with decreasing parasitaemia and less severe disease.
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