| Popis: |
The angiotensin II antagonists, a new group of drugs, block in a selective way AT receptors, causing vasodilatation, increase of renin and of angiotensin II, reduction of peripheral resistance, of the aldosterone levels, and of blood pressure without modifying heart rate. All of them act in a similar way and share the same pharmacological actions, excepting a mild uricosuric effect of losarten, a prototype of these compounds. These antihypertensive drugs are as efficent as the rest of the drugs used to treat high blood pressure with the advantage that patients tolerate them better. They seem to regress left ventricular hypertrophy and to be at least as effective as ECA inhibitors for the treatment of congestive heart failure. The cost of these drugs is high. |
