Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson’s Disease

Autor: François D. H. Gould, Andrew Gross, Rebecca Z. German, Jason R. Richardson
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Parkinson's Disease, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2090-8083
2042-0080
DOI: 10.1155/2018/6537072
Popis: Swallowing disorders in Parkinson’s disease are not responsive to dopamine depletion therapy and contribute to morbidity. They are poorly understood owing to a lack of adequate models. We present the first evidence of oropharyngeal changes in a rotenone toxicity model of Parkinson’s disease. Rats were recorded while feeding before and after daily rotenone injections at two different doses (2.75 mg/kg and 3 mg/kg). The higher dose had a much more severe parkinsonian phenotype than the low dose. Timing and amplitude of chewing changed, as did the coordination of chewing and swallowing. Dose-dependent effects were evident. These preliminary results indicate that future research in toxicological models of Parkinson’s disease should incorporate the study of oropharyngeal dysfunction. A better understanding of nongenetic models of Parkinson’s disease in feeding may open new avenues for research into the neurological and behavioral bases for swallowing dysfunction in Parkinson’s disease.
Databáze: Directory of Open Access Journals
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