Vitamin D, parathyroid hormone, glucose metabolism and incident diabetes in the multiethnic study of atherosclerosis

Autor: Erin D Michos, Joshua J Joseph, Ian H de Boer, Alain G Bertoni, Justin Basile Echouffo-Tcheugui, Sherita H Golden, Guy Brock, Songzhu Zhao, David Kline, Amaris Williams, Valery S Effoe, Bryan Kestenbaum
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMJ Open Diabetes Research & Care, Vol 10, Iss 5 (2022)
Druh dokumentu: article
ISSN: 2052-4897
DOI: 10.1136/bmjdrc-2022-002931
Popis: Introduction Higher concentrations of serum 25-hydroxyvitamin D (25(OH)D) and lower concentrations of parathyroid hormone (PTH) are associated with lower insulin resistance and incident diabetes in non-Hispanic White and Hispanic Americans. Results are mixed in other populations, with no observational studies in a large multiethnic cohort. The association of serum 25(OH)D with diabetes may vary by adiposity level.Research design and methods Among 5611 participants in the Multi-Ethnic Study of Atherosclerosis without diabetes at baseline, cross-sectional associations of serum 25(OH)D with homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA-β were examined using linear regressions. The association of 25(OH)D with incident diabetes over 9 years was examined using Cox proportional hazard regression.Results Black Americans had the highest proportion of individuals with 25(OH)D
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