The role of vitamin D supplementation for primary prevention of cancer: meta-analysis of randomized controlled trials

Autor: Tarek Haykal, Varun Samji, Yazan Zayed, Inderdeep Gakhal, Harsukh Dhillon, Babikir Kheiri, Josiane Kerbage, Vijaysai Veerapaneni, Michele Obeid, Rizwan Danish, Ghassan Bachuwa
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Community Hospital Internal Medicine Perspectives, Vol 9, Iss 6, Pp 480-488 (2019)
Druh dokumentu: article
ISSN: 2000-9666
20009666
DOI: 10.1080/20009666.2019.1701839
Popis: Background: In the USA cancer is the second leading cause of mortality, as such, primary prevention of cancer is a major public health concern. Vitamin D supplementation has been studied as a primary prevention method for multiple diseases including cardiovascular disease, osteoporosis, diabetes mellitus and cancer. The role of Vitamin D as primary prevention of cancer is still controversial. With fast emergence of large randomized controlled trials (RCTs) in that regards, we aimed to evaluate the efficacy of Vitamin D supplementation as primary prophylaxis for cancer. Methods: A comprehensive electronic database search was conducted for all RCTs where comparison of Vitamin D supplementation versus placebo for the prevention of any type of disease with at least 3 years of Vitamin D supplementation was used and where cancer incidence or mortality was reported. The primary outcome was cancer-related mortality and cancer incidence. We calculated risk ratios (RRs) and 95% confidence intervals (CIs) using a random-effects model at the longest follow-up. Results: We included 10 RCTs with 79,055 total patients, mean age of 68.07 years, a female percentage of 78.02% and a minimum follow-up of 4 years and more. Vitamin D was associated with significant reduction of cancer-related mortality compared with placebo (RR 0.87; 95% CI: 0.79–0.96; P = 0.05: I2 = 0%). Compared with placebo, Vitamin D was not associated with significant reduction of cancer incidence (RR: 0.96; 95% CI: 0.86–1.07; P = 0.46; I2 = 31%). Conclusion: With inclusion of studies, which did not primarily examine vitamin D for the purpose of preventing cancer or reducing cancer mortality our meta-analysis highlights that the use of vitamin D supplementation for primary prevention of cancer is encouraged as it does possibly decrease cancer-related mortality once cancer is diagnosed; however, it has no role or effect on cancer incidence.
Databáze: Directory of Open Access Journals
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