Cerebellar stimulation prevents Levodopa-induced dyskinesia in mice and normalizes activity in a motor network

Autor: Bérénice Coutant, Jimena Laura Frontera, Elodie Perrin, Adèle Combes, Thibault Tarpin, Fabien Menardy, Caroline Mailhes-Hamon, Sylvie Perez, Bertrand Degos, Laurent Venance, Clément Léna, Daniela Popa
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30844-0
Popis: Here, the authors studied how cerebellar stimulation alleviates levodopa-induced dyskinesia (LID). They demonstrated that Purkinje cell opto-stimulation is sufficient to prevent LID development and can normalize brain activity in a wide motor network in mice.
Databáze: Directory of Open Access Journals