Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation

Autor: Vanessa de Jesus, Nusrat S. Qureshi, Sven Warhaut, Jasleen K. Bains, Marina S. Dietz, Mike Heilemann, Harald Schwalbe, Boris Fürtig
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-25024-5
Popis: Translational regulation by riboswitches is an important mechanism for the modulation of gene expression in bacteria. Here the authors show that the ligand-induced allosteric switch in the adenine-sensing riboswitch from V. vulnificus is insufficient and leads only to a partial opening of the ribosome binding site and requires interaction with 30S-bound ribosomal protein S1, which acts as an RNA chaperone.
Databáze: Directory of Open Access Journals