Synthesis of sulfonylurea derivatives and their α-glucosidase inhibitory activity
| Autor: | Thi Thoi Bui, Dai Quang Ngo, Van Loc Tran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Vietnam Journal of Science, Technology and Engineering, Vol 62, Iss 2 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2525-2461 2615-9937 |
| DOI: | 10.31276/VJSTE.62(2).34-37 |
| Popis: | The paper describes the preparation of new sulfonylurea derivatives from sulfonyl carbamate 6 with amino derivatives. The process for synthesis of the key compound 6 included three steps starting from compound 6-chloronicotinic acid 1, which are readily available chemicals. The compound 1 in the presence of triethylamine in anhydrous acetone solvent and ethyl chloroformate to obtain 6-chloronicotinic (ethyl carbonic) anhydride compound 3. The compound 3 were subsequently reacted with compound 4 to obtain compounds 5. The sulfonamides 5 was refluxed with ethyl chloroformate in present anhydrous potassium carbonate in dry acetone to obtain the key compounds 6. The total yield of the key intermediate compound 6 is about 81.35%, related to the starting materials. Finally, three sulfonylurea derivatives 7a-c were synthesized by condensation of 6 with various of amines in toluene. Their structures have been determined by IR, MS and 1H and 13C NMR spectroscopic methods, and their α-glucosidase inhibitory activity have been evaluated. |
| Databáze: | Directory of Open Access Journals |
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