Desenvolvimento e caracterização de nanopartículas lipídicas destinadas à aplicação tópica de dapsona
| Autor: | Guilherme Soares dos Santos, Gabriela Garrastazu Pereira, Eduardo André Bender, Letícia Marques Colomé, Sílvia Stanisçuaski Guterres, Daniel Canema Manhães de Carvalho, Gilberto Weissmüller |
|---|---|
| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Química Nova, Vol 35, Iss 7, Pp 1388-1394 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1678-7064 0100-4042 |
| DOI: | 10.1590/S0100-40422012000700019 |
| Popis: | In this work, theospheres (innovative lipid nanoparticles) were prepared by the high pressure homogenization technique using different surfactants for dapsone encapsulation. Mean particle size ranged from 105 to 153 nm and negative zeta potentials were obtained for all theosphere formulations. Atomic force microscopy images confirmed the spherical shape of theospheres. The HPLC method used to determine dapsone-loaded theospheres was selective, linear, exact and precise. The entrapment efficiency of dapsone was 91.4%. Theospheres provided controlled release of idebenone (52.7 ± 1.6%) in comparison to the free drug (103.1 ± 1.9%). |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|