Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα

Autor:	Evangelos Pazarentzos
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.4161/23723556.2014.995020
Popis:	IκΒα (the protein product of NFKBIA gene) has widely been considered a pro- apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB. Our findings indicate that IκΒα also exerts a strong anti-apoptotic activity at the outer mitochondria membrane (OMM). This function we uncovered is distinct from its ability to sequester and inhibit NFκB. IκΒα instead binds to voltage dependent anion channel 1 (VDAC1) and Hexokinase 2 (HK2), stabilizes this complex and prevents mitochondria outer membrane permeabilisation (MOMP) and apoptosis.
Databáze:	Directory of Open Access Journals
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