Seven New Phenylhexanoids with Antioxidant Activity from Saxifraga umbellulata var. pectinata

Autor:	Jiao Huang, Donglin Chen, Mengying Liu, Yarui Yu, Yi Zhang, Jing Huang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Saxifraga umbellulata var. pectinate phenylhexanoid antioxidant activity Organic chemistry QD241-441
Zdroj:	Molecules, Vol 28, Iss 9, p 3928 (2023)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules28093928
Popis:	Seven new phenylhexanoids, (S)-(+)-3,4-dihydroxy-11-methoxyphenylhex-9-one (1), (E) 3,4-dihydroxy-phenylhex-10-en-9-one (2), (E)-4-hydroxyphenylhex-10-en-9-one (3), (R)-(−)-3,4,11-trihydroxyphenylhex-9-one 11-O-β-d-glucopyranoside (4), (R)-(−)-4,11-dihydroxyphenylhex-9-one 11-O-β-d-glucopyranoside (5), phenylhex-4,9,11-triol 11-O-β-d-glucopyranoside (6), and 9-O-acetyl-phenylhex-4,9,11-triol 11-O-β-d-glucopyranoside (7), were isolated and identified from Tibetan medicine Saxifraga umbellulata var. pectinate. The antioxidant activities of these compounds were evaluated using the DPPH and ABTS radical scavenging experiments. In the ABTS experiment, compounds 1 (IC50 13.99 ± 2.53 μM) and 2 (IC50 13.11 ± 0.94 μM) exhibited significantly better antioxidant activity than L-ascorbic acid (IC50 23.51 ± 0.44 μM).
Databáze:	Directory of Open Access Journals
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