HER2/neu expression status of post BCG recurrent non-muscle-invasive bladder urothelial carcinomas in relation to their primary ones

Autor: Mohamed Yousef Ali, Ahmed Yousef Aboelsaad, Ahmed M. Abdel Gawad, Tamer A. Abouelgreed, Ahmed A. El Gammal, Osama M. Ghoneimy, Eman M. El-Dydamony, Ahmed A Alrefaey, Eslam Mohamed, Sherif Azzam, Ayman Abdulmohaymen, Yasien Mohammed, Mohammed S. Abdelwahed, Ahmed Fawzi A. Elsayed, Basem A. Fathi, Nosaiba M. Abd Alrahim, Abeer S. Farag, Alaa R. Mahmoud, Hasan Ismail Mohamed, Seth Horsu, Abdulkarim Hasan
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Archivio Italiano di Urologia e Andrologia (2023)
Druh dokumentu: article
ISSN: 1124-3562
2282-4197
DOI: 10.4081/aiua.2023.11313
Popis: Background: Transurethral resection (TUR) followed by adjuvant therapy is still the treatment of choice of Non-Muscle-Invasive Bladder Urothelial Carcinoma (NMIBUC). However, recurrence is one of the most troublesome features of these lesions. Early second resection and adjuvant BCG therapy has been shown to improve the outcome. Objective: To evaluate the prognostic value of C-erbB-2 (HER2/neu) expression status in Non-Muscle-Invasive Bladder Urothelial Carcinoma cases, before and after intravesical Bacillus Calmette Guerin (BCG immunotherapy). Materials and methods: HER2/neu expression was studied in 120 (Ta-T1) Non-Muscle-Invasive Urothelial Carcinoma cases. The expression was evaluated and compared to the expression after Bacillus Calmette Guerin (BCG) immunotherapy. Results: HER2/neu expression in low and high grade of the Non- Muscle-Invasive Urothelial Carcinoma was (38%) and (83%) respectively. The difference of the expression rates by tumor grade was statistically significant. In recurring lesions post BCG therapy, C-erbB-2 expression was markedly decreased (31.6%) when compared to its expression before therapy (65%). Conclusions: The HER2/neu expression increased as the tumor grade rose. The reduction in expression following BCG treatment in Non-Invasive transitional cell carcinoma cases could reflect a reduction of the potential malignancy of the tumor.
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