Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology

Autor:	Loretta László, Anita Kurilla, Tamás Takács, Gyöngyi Kudlik, Kitti Koprivanacz, László Buday, Virag Vas
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	KRAS colorectal cancer RAS signalling cancer stem cells RAS-driven metastasis CRC with age Cytology QH573-671
Zdroj:	Cells, Vol 10, Iss 3, p 667 (2021)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells10030667
Popis:	The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming to collect recent data on KRAS-driven enhanced cell signalling, in vitro and in vivo research models, and CRC development-related processes such as metastasis and cancer stem cell formation. We attempt to cover the diverse nature of the effects of KRAS mutations on age-related CRC development. As the incidence of CRC is rising in young adults, we have reviewed the driving forces of ageing-dependent CRC.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2f4d58052aef446f8f210e198c0eadac Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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