Dual pH/redox-responsive hyperbranched polymeric nanocarriers with TME-trigger size shrinkage and charge reversible ability for amplified chemotherapy of breast cancer

Autor:	Fahimeh Badparvar, Ahmad Poursattar Marjani, Roya Salehi, Fatemeh Ramezani
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Nano drug delivery systems (NDDSs) pH/redox dual-responsive Copolymeric nanoparticles Tumor microenvironment (TME) Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-57296-4
Popis:	Abstract A novel pH/redox-responsive hyperbranched MeO-PEG-b-(NIPAAm-co-PBAE) nanoparticles (NPs) were designed with size shrinkage and charge-reversible potential for targeted delivery of docetaxel (DTX) to MDA-MB-231 cell lines. In the tumor microenvironment (TME), amine protonation induces charge reversal and disulfide bond cleavage under high TME GSH concentration causing size shrinkage, improved deep tumor penetration, and active targeting of the therapeutic agents. These nano drug delivery systems (NDDSs) significantly promoted cancer cell uptake (~ 100% at 0.5 h), facilitating site-specific delivery and deep tumor penetration. The MTT assay revealed significantly higher cytotoxicity (P value
Databáze:	Directory of Open Access Journals
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