| Autor: |
Chang-Kwon Oh, Jun Bae Bang, Sung-Joo Kim, Kyu Ha Huh, Soo Jin Kim, Jin Seok Jeon, Sang Youb Han, Hong Rae Cho, Young Joo Kwon, Su Hyung Lee, Yu Seun Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Asian Journal of Surgery, Vol 43, Iss 6, Pp 660-667 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1015-9584 |
| DOI: |
10.1016/j.asjsur.2019.07.011 |
| Popis: |
Summary: Background: Many immunosuppressive drugs are prescribed as twice-daily dosing. A simplified once-daily dosing of immunosuppressive drug regimen may improve medication adherence. We investigated medication adherence of simplified once-daily immunosuppressive regimen consisting of extended-release tacrolimus, sirolimus, and corticosteroids along with the efficacy and safety of this regimen. Methods: This study was a prospective, multicenter, controlled and cohort trial. Stable kidney transplant recipients who had received transplantation at least 3 months before the study enrollment were eligible for the study. Participants were required to fill-out the self-reported immunosuppressant therapy barrier scale (ITBS) questionnaire before and after the conversion. Other clinical laboratory parameters and adverse events were evaluated until 6 months post-conversion. Results: A total of 160 kidney recipients comprised the intention-to-treat population. The mean total ITBS score was 19.5 ± 4.0 at pre-conversion and 6 months after converting, the mean total ITBS score was 16.6 ± 3.6 (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
